FORMULASI TABLET HISAP EKSTRAK ETANOL DAUN KEMANGI (Ocimum sanctum L.) DENGAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET

Abstract

So far the basil plant (Ocimum sanctum L.) is used by the community as fresh vegetables with the aim of overcoming the problem of bad breath. Ethanol extract in basil can inhibit the growth of pathogenic bacteria in the mouth. This study aims to make lozenges of basil extract with different concentrations of CMC-Na as a binder and to determine the effect of CMC-Na concentrations on the physical properties of lozenges. Lozenges were made by wet granulation method with 0% CMC-Na binder variation for formula I; 1% for formula II; 3% for formula III; 5% for IV formulas; 7% for formula V. Granules are compressed using a single punch tablet machine. The results showed that the use of CMC-Na as a binder in the manufacture of lozenges of basil extract in all formulas produced lozenges that met the requirements, except formulas I and II. The best hardness test results were in formula V with a value of 5.28 kg/cm2 while for the best friability test in formula IV with a value of 0.32%. The best dissolving time test results were in formula V with a dissolving time of 6 minutes 33 seconds. The results of the taste response test showed that formula V had the most delicious taste response. The effect of binder concentration can affect the physical properties of the tablet. Variations in binder have an influence on each formula. The greater the binder, the level of hardness increases.